2023
Geras A, Darvish Shafighi S, Domżał K, Filipiuk I, Rączkowski Ł, Szymczak P, Toosi H, Kaczmarek L, Koperski Ł, Lagergren J, Nowis D, Szczurek E. Celloscope: a probabilistic model for marker-gene-driven cell type deconvolution in spatial transcriptomics data. Genome Biol. 2023 May 17;24(1):120. doi: 10.1186/s13059-023-02951-8. PMID: 37198601
Wysocki PT, Czubak K, Marusiak AA, Kolanowska M, Nowis D. lncRNA DIRC3 regulates invasiveness and IGF signaling in thyroid cancer cells. Endocr Relat Cancer. 2023 May 1:ERC-23-0058. doi: 10.1530/ERC-23-0058. PMID: 37130273
Paterek A, Oknińska M, Pilch Z, Sosnowska A, Ramji K, Mackiewicz U, Golab J, Nowis D, Mączewski M. Arginase Inhibition Mitigates Bortezomib-Exacerbated Cardiotoxicity in Multiple Myeloma. Cancers (Basel). 2023 Apr 6;15(7):2191. doi: 10.3390/cancers15072191.
2022
Hunia J, Gawalski K, Szredzka A, Suskiewicz MJ, Nowis D. The potential of PARP inhibitors in targeted cancer therapy and immunotherapy. Front Mol Biosci. 2022 Dec 1;9:1073797. doi: 10.3389/fmolb.2022.1073797. eCollection 2022. PMID: 36533080
Ramji K, Grzywa TM, Sosnowska A, Paterek A, Okninska M, Pilch Z, Barankiewicz J, Garbicz F, Borg K, Bany-Laszewicz U, Zerrouqi A, Pyrzynska B, Rodziewicz-Lurzynska A, Papiernik D, Sklepkiewicz P, Kedzierska H, Staruch A, Sadowski R, Ciepiela O, Lech-Maranda E, Juszczynski P, Mackiewicz U, Maczewski M, Nowis D*, Golab J*. Targeting arginase-1 exerts antitumor effects in multiple myeloma and mitigates bortezomib-induced cardiotoxicity. Sci Rep. 2022 Nov 16;12(1):19660. doi: 10.1038/s41598-022-24137-1.
Sokolowska O, Rodziewicz-Lurzynska A, Pilch Z, Kedzierska H, Chlebowska-Tuz J, Sosnowska A, Szumera-Cieckiewicz A, Sokol K, Barankiewicz J, Salomon-Perzynski A, Ciepiela O, Lech-Maranda E, Golab J, Nowis D. Immune checkpoint inhibition improves antimyeloma activity of bortezomib and STING agonist combination in Vk*MYC preclinical model. Clin Exp Med. 2022 Aug 31. doi: 10.1007/s10238-022-00878-1. PMID: 36044158
Kumari R, Grzywa TM, Małecka-Giełdowska M, Tyszkowska K, Wrzesień R, Ciepiela O, Nowis D, Kaźmierczak P. Ablation of Tmcc2 Gene Impairs Erythropoiesis in Mice. Int J Mol Sci. 2022 May 9;23(9):5263. doi: 10.3390/ijms23095263.
Mehlich D, Marusiak AA. Kinase inhibitors for precision therapy of triple-negative breast cancer: Progress, challenges, and new perspectives on targeting this heterogeneous disease. Cancer Lett. 2022 Oct 28;547:215775. doi: 10.1016/j.canlet.2022.215775. Epub 2022 Jun 3.
2021
Mehlich D, Łomiak M, Sobiborowicz A, Mazan A, Dymerska D, Szewczyk ŁM, Mehlich A, Borowiec A, Prełowska MK, Gorczyński A, Jabłoński P, Iżycka-Świeszewska E, Nowis D, Marusiak AA. MLK4 kinase regulates the DNA damage response and promotes triple-negative breast cancer chemoresistance. Cell Death Dis. 2021 Nov 27;12(12):1111. doi: 10.1038/s41419-021-04405-0.
Grzywa TM, Sosnowska A, Rydzynska Z, Lazniewski M, Plewczynski D, Klicka K, Malecka-Gieldowska M, Rodziewicz-Lurzynska A, Ciepiela O, Justyniarska M, Pomper P, Grzybowski MM, Blaszczyk R, Wegrzynowicz M, Tomaszewska A, Basak G, Golab J, Nowis D. Potent but transient immunosuppression of T-cells is a general feature of CD71+ erythroid cells. Commun Biol. 2021 Dec 10;4(1):1384. doi: 10.1038/s42003-021-02914-4.
Szydłowski M, Garbicz F, Jabłońska E, Górniak P, Komar D, Pyrzyńska B, Bojarczuk K, Prochorec-Sobieszek M, Szumera-Ciećkiewicz A, Rymkiewicz G, Cybulska M, Statkiewicz M, Gajewska M, Mikula M, Gołas A, Domagała J, Winiarska M, Graczyk-Jarzynka A, Białopiotrowicz E, Polak A, Barankiewicz J, Puła B, Pawlak M, Nowis D, Golab J, Tomirotti AM, Brzózka K, Pacheco-Blanco M, Kupcova K, Green MR, Havranek O, Chapuy B, Juszczyński P. Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies. Cancer Res. 2021 Oct 8:canres.1023.2021. doi: 10.1158/0008-5472.CAN-21-1023.
Sosnowska A, Chlebowska-Tuz J, Matryba P, Pilch Z, Greig A, Wolny A, Grzywa TM, Rydzynska Z, Sokolowska O, Rygiel TP, Grzybowski M, Stanczak P, Blaszczyk R, Nowis D*, Golab J*. Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma. Oncoimmunology. 2021 Jul 24;10(1):1956143. doi: 10.1080/2162402X.2021.1956143
Prelowska MK, Mehlich D, Ugurlu MT, Kedzierska K, Cwiek A, Kosnik A, Kaminska K, Marusiak AA, Nowis D. Inhibition of the ʟ-glutamine transporter ASCT2 sensitizes plasma cell myeloma cells to proteasome inhibitors. Cancer Lett. 2021;507:13-25. doi: 10.1016/j.canlet.2021.02.020.
Materna-Kiryluk A, Pollak A, Gawalski K, Szczawinska-Poplonyk A, Rydzynska Z, Sosnowska A, Cukrowska B, Konopka E, Pietrucha B, Grzywa TM, Banaszak-Ziemska M, Niedziela M, Skalska-Sadowska J, Stawiński P, Nowis D, Ploski R. Mosaic IL6ST variant inducing constitutive GP130 cytokine receptor signaling as a cause of neonatal onset immunodeficiency with autoinflammation and dysmorphy. Hum Mol Genet. 2021 Jan 30:ddab035. doi: 10.1093/hmg/ddab035. PMID: 33517393
Grzywa TM, Nowis D, Golab J. The role of CD71+ erythroid cells in the regulation of the immune response. Pharmacol Ther. 2021 Jun 22:107927. doi: 10.1016/j.pharmthera.2021.107927.
Grzywa TM, Justyniarska M, Nowis D, Golab J. Tumor Immune Evasion Induced by Dysregulation of Erythroid Progenitor Cells Development. Cancers (Basel). 2021;13(4):870. doi: 10.3390/cancers13040870.
2020
Pilz M , Kwapiszewska K , Kalwarczyk T , Bubak G , Nowis D , Hołyst R. Transport of nanoprobes in multicellular spheroids. Nanoscale. 2020 Oct 14;12(38):19880-19887. doi: 10.1039/d0nr01986k. PMID: 32975267
Pancheri E, Guglielmi V, Wilczynski GM, Malatesta M, Tonin P, Tomelleri G, Nowis D*, Vattemi G*. Non-hematologic toxicity of bortezomib in multiple myeloma: the neuromuscular and cardiovascular effects. Cancers (Basel). 2020;12(9):2540. doi: 10.3390/cancers12092540.
Skirecki T, Swacha P, Hoser G, Golab J, Nowis D, Kozłowska E. Bone Marrow is the Preferred Site of Memory CD4+ T-Cells Proliferation During Recovery from Sepsis. JCI Insight 2020;5(10):e134475. doi.org/10.1172/jci.insight.134475.
Grzywa TM, Sosnowska A, Matryba P, Rydzyńska Z, Jasiński M, Nowis D*, Gołąb J*. Myeloid cell-derived arginase in cancer immune response. Front. Immunol. 2020; 11:938. doi: 10.3389/fimmu.2020.00938
Bilska A, Kusio-Kobiałka M, Krawczyk PS, Gewartowska O, Tarkowski B, Kobyłecki K, Nowis D, Golab J, Gruchota J, Borsuk E, Dziembowski A, Mroczek S. Immunoglobulin Expression and the Humoral Immune Response Is Regulated by the Non-Canonical poly(A) Polymerase TENT5C. Nat Commun. 2020 Apr 27;11(1):2032. doi: 10.1038/s41467-020-15835-3.
Matryba P, Wolny A, Sosnowska A, Bożycki Ł, Greig A, Grzybowski J, Stefaniuk M, Nowis D, Golab J. Systematic evaluation of chemically distinct tissue optical clearing techniques in murine lymph nodes. J Immunol. 2020;204(5):1395-1407. doi: 10.4049/jimmunol.1900847. PMID: 31953352
Sikorski PJ, Warminski M, Kubacka D, Ratajczak T, Nowis D, Kowalska J, Jemielity J.The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5’ cap modulates protein expression in living cells. Nucleic Acids Res. 2020 Feb 28;48(4):1607-1626. doi: 10.1093/nar/gkaa032. NAR Breakthrough Paper
2019
Czystowska-Kuzmicz M, Sosnowska A, Nowis D, Ramji K, Szajnik M, Chlebowska-Tuz J, Wolinska E, Gaj P, Grazul M, Pilch Z, Zerrouqi A, Graczyk-Jarzynka A, Soroczynska K, Cierniak S, Koktysz R, Elishaev E, Gruca S, Stefanowicz A, Blaszczyk R, Borek B, Gzik A, Whiteside T, Golab J. Small extracellular vesicles-containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma. Nat Commun. 2019 Jul 5;10(1):3000. doi: 10.1038/s41467-019-10979-3. PMID: 31278254
Marusiak AA, Prelowska MK, Mehlich D, Lazniewski M, Kaminska K, Gorczynski A, Korwat A, Sokolowska O, Golab J, Biernat W, Plewczynski D, Brognard J, Nowis D. MLK4 drives aggressiveness of triple-negative breast cancer through NF-κB dependent mechanism. Oncogene. 2019 Apr;38(15):2860-2875. doi: 10.1038/s41388-018-0618-0.
2018
Szczałuba K, Chmielewska JJ, Sokolowska O, Rydzanicz M, Szymańska K, Feleszko W, Włodarski P, Biernacka A, Murcia Pienkowski V, Walczak A, Bargeł E, Królewczyk K, Nowacka A, Stawiński P, Nowis D, Dziembowska M, Płoski R. Neurodevelopmental phenotype caused by a de novo PTPN4 point mutation disrupting protein localization in neuronal dendritic spines. Clin Genet. 2018; Sep 21. doi: 10.1111/cge.13450
Chlebowska-Tuz J, Sokolowska O, Gaj P, Lazniewski M, Firczuk M, Borowiec K, Sas-Nowosielska H, Bajor M, Malinowska A, Muchowicz A, Ramji K, Stawinski P, Sobczak M, Pilch Z, Rodziewicz-Lurzynska A, Zajac M, Giannopoulos K, Juszczynski P, Basak GW, Plewczynski D, Ploski R, Golab J*, Nowis D*. Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells. Haematologica. 2018 Nov;103(11):1843-1852. doi: 10.3324/haematol.2018.190231. PMID: 30002127
Waligora M, Koperny M, Jaeschke RR, Wozniak A, Piasecki J, Sliwka A, Mitus JW, Wasylewski MT, Strzebonska K, Polak M, Nowis D, Fergusson D, Bala MM, Kimmelman J. Risk and Surrogate Benefit for Pediatric Phase 1 Trials in Oncology: A Systematic Review with Meta-analysis. PLoS Med 2018; 15(2): e1002505. https://doi.org/10.1371/journal.pmed.1002505. PMID: 29462168
Guglielmi V, Voermans NC, Oosterhof A, Nowis D, van Engelen BG, Tomelleri G, Vattemi G.. Evidence of ER stress and UPR activation in patients with Brody disease and Brody syndrome. Neuropathology and Applied Neurobiology 2018 Aug;44(5):533-536. doi: 10.1111/nan.12431.
Sokolowska O, Nowis D. STING signaling in cancer cells - important or not? Arch Immunol Ther Exp (Warsz). 2018 Apr;66(2):125-132. doi: 10.1007/s00005-017-0481-7. PMID: 28748479